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* For patients with creatinine clearance <15 mL/min, reduce daily dose in proportion to creatinine clearance (eg, patients with a creatinine clearance of 75 mL/min should receive one-half the daily dose that patients with a creatinine clearance of 15 mL/min receive).

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However, the integration of behavioral and pharmacological treatments may ultimately prove to be the most effective approach.

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